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Department of Engineering and System Science NTHU
Welcome to ESS site
Professor Fu-Rong Chen,

Fu-Rong Chen, Distinguished Professor

Materials Science and Engineeringand System Science SUNY at Stony Brook, NY

Research interests

  • 3D atomic resolution electron microscopy
  • Design and manufacture of Table top Electron microscope
  • Soft Materials Electron Microscopy
  • Energy Saving Electrochromics Smart Glass

ESS 410






1976/09~1980/07 Dept. of Materials Science and Engineering and System Science National Tsing Hua University
1980/09~1986/07 Dept. of Materials Science and Engineeringand System Science SUNY at Stony Brook, NY
1986/09~1988/07 Post Doc., Dept. of Materials Science and Engineering and System Science, MIT

Current position

Distinguished Professor, ​Department of Engineering and System Science, National Tsing Hua University


1988/07~1990/09: Research professor, Dept. of Materials Science and Engineering and System Science, Northwestern University
1990~ present: Professor, National Tsing Hua University
2005~2014: Joint Research Fellow: National Synchrotron Research Center
2005~2014: Joint Research Fellow: Dept. of Physics, Academic Science
2010-present: Technology consultant, Industrial Technology Research Institute

Major awards and honors

1986        Research Award of Stony Brook

1999-2014   MRS, symposium organizer

2005        The Highest Research award from NSC, Engineering division

2005-2007  The Highest award from NSC, Engineering division.

2011        Award for excellent professor (administration of Education & NTHU)

2012        The Highest Research award from MOST

2012        The Distinguished Professor of Tsing Hua University

2013        European Microscopy Society Outstanding paper Award

2013        MOST:Excellent Research and Academic Award in Nanotechnology

2013        MOST:Excellent Start-Up Company award in NanotechnologyandExcellent Start-Up Company Award

2015        Institute for Biotechnology and Medicine Industry: The 12th national prize for enterprise innovation(Nereuscope : fluid/ fluorescent confocal electron microscope)

2016       The 51th San-Yat Sen Academic and Cultural Foundation Award: Science Category

2017       The 24th Congress and General Assembly of International Union of Crystallography, symposium organizer, MS-105 New instrumental developments for electron crystallography on 27 August 2017, Hyderabad, India




  • Big Bang Tomogranphy” in process of application with Professor Dirk Van Dyck through the support of University of Antwerp.
  • Joint patent with JEOL “Design and fabrication of Boersch phase plate in TEM, in the process of application


Evidence of Impact (2011-2016)

The  evidence  of  impact  can  be  catalogued  two  parts  (a)  the  Academics  (b)  the  Industrial technologies

A.  Academics: 21 invited talks at international conference (2011-2016)

31 SCI papers (2011-2016)

The  objective  of  my  research  is  establishing  theory  and  methodology  of  low  dose  electron holography for the atomic resolution tomography of soft materials. In the late 1950s Richard Feynman pointed out that ‘It would be very easy to make an analysis of any complicated chemical substance; all one would have to do would be to look at it and see where the atoms are.’ In principle, the latest generation aberration-corrected transmission electron microscopes can achieve this goal but for a variety of reasons one is still far away from a reliable method that would meet Feynmans challenge of extracting the three-dimensional (3D) position of all the atoms in an object, to understand its physical and chemical properties. A most noticeable bottleneck is the large accumulated electron dose required to produce tilt series of atomic resolution images, because electron dose rates are commonly chosen large (104–105 2 s -1) to achieve a needed resolution around 1 Å and single atom sensitivity. Any such single image can exhibit uncontrolled electron beam-induced surfaces alterations or even bulk modifications, in particular if particles are small or for the organic materials such as protein or molecules.   For biological sample, protein, the 3D structure are usually reconstructed from images recorded at the cryo-mode to slow down  the electron radiation damage. The 3D structure of bacteriophage T4 was reconstructed using the cryo- electron  microscopy  in  2005,(V.A.Kostyuchenko  et  al.  Nature  Struct.  Mol.  Biol.12,810813(2005)). But drawbacks of cryo-microscopy is that at the low temperature , the shape of the protein will be deformed. And the proteins are required exists high symmetry.

In the academic development, to address Feynmans dream, I have devoted myself in the development of the technology and theory of low-dose electron holography targeting for recovering 3D atomic structure and shape of soft materials like protein, RNA/ DNA, single molecule etc. at room temperature without suffering the radiation damage from electron beam. The shape of the protein and DNA/ RNA will be preserved.

In 2012 we start having the first paper related to reconstruction of 3D atomic structure based on big- bang theory published in NATURE. Later in 2016, we published a general theory for atomic resolution tomography for nano-crystalline material in NATURE communication. A series of papers along this trend will appear in the NATURE or its sub-journals toward understand the 3D shape at atomic resolution for the soft materials in clouding protein, single molecule, DNA/ RNA etc.

B. Industrial Technology:

Established a “Energy Saving Smart Window and Transparent Display” company 2006-present) Established a “Electron Optics Instrumentation Company” for Tabletop electron microscope (2012-present)

I started up high-end technological companies with my graduate students in 2006 for energy saving smart window and 2012 for tabletop electron microscope. One end students can develop their own career and set up strong industrial foundation in Taiwan, on the other hand, the new innovated  company  can  reward  their  profit  back  to  university  laboratory  to  compensate  the insufficient fund from government

At this moment, electronchromics smart window company targeting for the energy saving has been well developed and has been profitable now. We are setting up mass manufacture production lines in HangZhou,   China. This team is a nice model for industrialization of nanotechnology for energy saving.  Beside this case, an electron optics team got the support from our MOST projects from 2010, and established as the first electron microscope manufacture company in Taiwan under the support of Industrial Technology Investment Company (ITIC) in 2012. This company has several important patents and unique technologies which lead to receive many awards. Recently, the world largest semiconductor fabrication company TSMC has given their order to our electron microscope company which proves a positive certificate for the established technologyIn the near future, these two companies will feedback their profit back to the laboratory to establish the world class academic research institute in materials science and scientific instrument in Taiwan.


Invited Talks in international conferences (Selected list from 21 invited talks, 2011-2016)

1. Fu-Rong Chen, The 24th Congress and General Assembly of International Union of Crystallography, Symposium MS “Electron Tomography at low dose, title: “ Low Dose Electron Holography for 3D atomic structure of soft materials”, on 27 August 2017, Hyderabad, India

2.Fu-Rong Chen, The 11th Asia-Pacific Microscopy Conference (APMC 11), “Atomic Resolution Tomography of Nanoparticles Reconstructed from Exit Wave “, Phuket, Thailand, May 23- May 27, 2016

3.Fu-Rong Chen, Second East-Asia Microscopy Conference (EAMC 2), “In-Line Electron Holography at Low Dose: Dynamics and Shape of Nanomaterials at Atomic Resolution“, Himeji, Japan, Nov.23-Nov.28, 2015

4.Fu-Rong Chen, Beijing Conference and Exhibition on Instrumental Analysis (BCEIA 2015) “Low Dose Electron Holography: 3D Shape and Dynamics of Nanomaterials at Atomic Resolution “ Beijing, China, Oct.27-Oct.30, 2015

5.Fu-Rong Chen, The 9th ATOM Workshop, “Shape of Nano-particles and Dynamics of Graphene at atomic Resolution “ Antwerp, Belgium, Sep.26-Oct. 04, 2015

6.Fu-Rong Chen, XXIV International Materials Research Congress 2015, Atomic Resolution Tomography: Retrieval of 3D Atomic Structure and Shape From an Exit Wave “ Cancun, Mexico, Aug. 16-20, 2015

7. Fu-Rong Chen, The 1st SALVE Symposium (Sub-Angstrom Low-Voltage Electron Microscopy), Ulm University, W. Germany, Feb. 17-18, 2015

8. Fu-Rong Chen, The 18th International Microscopy Congress IMC, 2014 “3D Electron Microscopy for Shape of Nanoparticle at Atomic Resolution “, Prague, Czech republic, Sep. 7th-12th, 2014

9. Fu-Rong Chen, The XX11 International Material Research Congress 2013 - (IMRC 2013), “From 2D exit wave to 3D atomic structure” Cancun, Mexico, Aug. 11-16, 2013

10. Fu-Rong Chen, Microscopy & Microanalysis (M&M 2012), “New Phase Microscopy for Advanced Soft Materials Imaging Using Tunable Boersch Electrostatic Phase Plate”, Phoenix, AZ, USA, July 29-Aug.2, 2012

11. Fu-Rong Chen, The 3rd ATOM Workshop on Exit Wave Restoration, “Big-Bang Tomography”, Rome, Italy, May 19-20, 2011


Publications (Selected list from 31 publications, 2011-2016)


Electron Microscopy:

1. Liu-Gu Chen, Angus Kirkland, Dirk Van Dyck, Fu-Rong Chen , Snapshot electron tomography for atomic resolution dynamics of graphene, Nature Materials, in review process. (corresponding author)

2. Chun-Ying Tsai, Yuan-Chih Chang, Ivan Lobato, Dirk Van Dyck, Fu-Rong Chen* . “Hollow Cone Electron Imaging for Single Particle 3D Reconstruction of Proteins. “ Scientific Reports(2016) 6:27701, DOI: 10.1038/srep27701,P.1-9. (corresponding author)

3. F.-R. Chen*, D. Van Dyck, C. Kisielowski, In-line three-dimensional holography of nanocrystalline objects at atomic resolution. Nature Communications, DOI: 10.1038/ ncomms10603 (2016) p.1-11 (corresponding author)

4. Dirk Van Dyck*, Joerg R. Jinschek, Fu-Rong Chen* , 'Big-Bang' tomography as a new route to atomic-resolution electron tomography. Nature, 486, (2012) p.243-246. (SCI) (corresponding author)

5. Wei-Yu Chang, Fu-Rong Chen* , Wide-range tunable magnetic lens for tabletop electron microscope. Ultramicroscopy, 171, (2016) p.139-145. (corresponding author)

6. Dirk Van Dyck*, Ivan Lobato*, Fu-Rong Chen*, Christian Kisielowski* (2014, Sep). Do you believe that atoms stay in place when you observe them in HRTEM? Micron, 68 (2014) 158-163.  (corresponding author)

7. F.-R. Chen*, C. Kisielowske*, D. Van Dyck*. 3D reconstruction of nanocrystalline particles form a single projection. Micron, 68(2014) 59-65. (corresponding author)

8. A.Wang, F. R. Chen, S. Van Aert, D. Van Dyck. Direct structure inversion from exit waves. Part II: A practical example. Ultramicroscopy 116,  (2012) P. 77-85. (SCI). (thesis advisor of A. Wang)

9. A. Wang*, F.R. Chen, S. Van Aert, D. Van Dyck. A method to determine the local surface profile from reconstructed exit waves. Ultramicroscopy, 111 (2012) p.1352-1359. (SCI). (thesis advisor of A. Wang)

Materials Science:

1. T. K. Chen*, C. C. Chang, H. H. Chang, A. H. Fang, C. H. Wang, W. H. Chao, C.M. Tseng, Y. C.

Lee, Y. R. Wu, M. H. Wen, H. Y. Tang, F. R. Chen, M. J. Wang, M. K. Wu*, and D. Van Dyck. Fe-vacancy order and superconductivity in tetragonal β-Fe1-xSe. Proceeding National Academic Science, 111, (2014)  63-68. (TEM advisor of T. K. Chen)

2. Shih-Yi Liu, Pijus Kundu, Tsu-Wei Huang, Yun-Ju Chuang, Fan-Gang Tseng, Yue Lu, Man-Ling Sui, Fu-Rong Chen , Quasi-2D Liquid Cell for High Density Hydrogen Storage, Nano Energy., in press (2016) (corresponding author)

3. Zhenhua Zhang, Hua Guo, Wenqiang Ding, Bin Zhang, Yue Lu, Xiaoxing Ke, Weiwei Liu, Fu- Rong Chen*, & Manling Sui* , Nanoscale Engineering in VO2 nanowires via Direct Electron Writing Process, Nano Lett., in press (Corresponding author)

4. Ping-Ray Chiang, Tsai-Yu Lin, Hsieh-Chih Tsai, Hsin-Lung Chen*, Shih-Yi Liu, Fu-Rong Chen, Yih-Shiou Hwang and I-Ming Chu* (2013, Dec). Thermosensitive Hydrogel froOligopeptide-Containing Amphiphilic Block Copolymer: Effect of Peptide Functional Group on Self-Assembly and Gelation Behavior. Langmuir, (2013), 29, 15981-15991.

5. Tsu-Wei Huang, Shih-Yi Liu, Yun-Ju Chuang, Hsin-Yi Hsieh, Chun-Ying Tsai, Wei-Jung Wu, Cheng-Ting Tsai, Utkur Mirsaidov, Paul Matsudaira, Chia-Shen Chang, Fan-Gang Tseng* and Fu-Rong Chen*. Dynamics of hydrogen nanobubbles in KLH protein solution studied with in situ wet-TEM. Soft Matter, 9, 37, (2013) p.8856-8861. (corresponding author)

6. Sung-Yen Wei, Sheng-Min Yu, Li-Chi Yu, Wen-Ching Sun, Chien-Kuo Hsieh, Tzer-Shen Lin, Chuen-Horng Tsai and Fu-Rong Chen* (2012, May). Ultrafast Al(Si)-Induced Crystallisation Process At Low Temperature. CrystEngComm, 14(15), 4967-4971. (SCI). (Corresponding author)

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